WebSolving the crystal structure of αKlotho and βKlotho will facilitate the development of agonists and antagonists of endocrine FGFs, which will be potentially useful for the treatment of various... WebFeb 28, 2024 · Interestingly, while klotho has primarily been studied in the context of inflammatory kidney diseases, the alpha-klotho form of the protein is highly abundant within the choroid plexus of the brain.
The Klotho proteins in health and disease - Nature
WebApr 4, 2024 · Klotho is expressed in the human heart and its expression level is mediated by TGF-beta1, is associated with the degree of chronic kidney disease and cardiac fibrosis. sKL induces the expression of markers of bone differentiation (BMP2, RUNX2, ALP, COL1A, and osteocalcin) in osteoblast MC3T3 cells. WebJan 20, 2024 · Therefore, Klotho is postulated as a very promising new target for future therapeutic strategies against oxidative stress, mitochondria abnormalities, and cellular … tagerly.com
Klotho: Hope For Increased Longevity And Reduced ... - Forbes
WebMar 16, 2024 · Fibroblast Growth Factor 23 (FGF23) and Klotho play an essential role in the regulation of mineral metabolism, and both are altered as a consequence of renal failure. FGF23 increases to augment phosphaturia, which prevents phosphate accumulation at the early stages of chronic kidney disease (CKD). WebApr 15, 2024 · KLOTHO-VS heterozygosity (KL-VShet+) promotes longevity and protects against cognitive decline in aging. To determine whether KL-VShet+ mitigates Alzheimer’s disease (AD) progression, we used longitudinal linear-mixed models to compare the rate of change in multiple cognitive measures in AD patients stratified by APOE ε4 carrier status. WebFig. 1. The bone–kidney–parathyroid endocrine axes mediated by FGF23 and Klotho. Active vitamin D (1,25-dihydroxyvitamin D3) binds to the vitamin D receptor (VDR) in osteocytes. The ligand-bound VDR forms a heterodimer with a nuclear receptor RXR and transactivates the FGF23 gene expression. FGF23 secreted from bone acts on the Klotho–FGFR … tagerim mon compte