WebFeb 14, 2007 · Mo et al. indicated that Tamm-Horsfall protein (THP) knockout mice generated calcium oxalate (CaOx) stones in the kidney by introducing 1% ethylene glycol and vitamin D3. The establishment of a system to induce kidney stones in normal mice is very important since the system can verify whether the process of kidney stone formation …
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WebEthylene Glycol; Calcium Oxalate; Methanol; View all Topics. Add to Mendeley. Set alert. ... may also be formed in vivo as a result of the normal metabolism and biotransformation of ethylene glycol and several other compounds (e.g., ascorbic acid, glycerol, ... young mice are fed a diet containing 0.2–0.3% cuprizone for 5–6 weeks, which ... WebCalcium oxalate monohydrate crystals, and not the oxalate ion, are responsible for the membrane damage and cell death observed in normal human and rat PT cells and suggest that calcium oxalate monohydrate crystals accumulation in the kidney is responsible for the renal toxicity associated with ethylene glycol exposure (Citation 6).
Webethylene glycol in pregnant mice did not indicate developmental effects. ... Typical renal effects included oxalate crystal deposition and renal tubular dilation, vacuolation, and degeneration. Oxalate, a metabolite of glycolic acid, forms a precipitate in the presence of calcium, and the deposition of these crystals in the renal tubules are ... WebEthylene glycol oxalate C4H4O6 CID 129641534 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ...
WebNov 1, 2024 · Genome wide analysis of mice kidneys with hyperoxaluria induced by the administration of glyoxalate showed at least 2-fold increase in the expression of 25 genes during deposition of CaOx crystals. ... Yang L (2002) Decreased renal expression of the putative calcium oxalate inhibitor Tamm-Horsfall protein in the ethylene glycol rat … WebFreel, Robert W., Whittamore, Jonathan M., Hatch, Marguerite. Transcellular oxalate and Cl − absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate. American journal of physiology, Gastrointestinal and liver physiology, vol.305, no.7, G520-G527.
WebCase Report Acute oxalate nephropathy caused by ethylene glycol poisoning Jung Woong Seo1, Jong-Ho Lee1,n, In Sung Son1, Yong Jin Kim1, Do Young Kim1, Yong Hwang1, Hyun Ah Chung1, Hong Seok Choi1, So Dug Lim2 1 Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea 2 Department of Pathology, Konkuk …
WebJ.J. Devlin, M. Schwartz, in Encyclopedia of Toxicology (Third Edition), 2014 Reproductive Toxicity. Ethylene glycol polymers with large carbon chains may be reproductive toxins, but ethylene glycol itself exhibits no developmental toxicity or detrimental effects to reproductive health in humans. Mice exposed to >1000 mg m −3 of ethylene glycol for … how to edit a pages documentWebMaterials and methods. The leaf extract was standardized by HPLC. Urolithiasis was induced in rats by administration of 0.75% v/v of ethylene glycol (EG) in distilled water and in addition, vehicle or methanol (CAME) or aqueous (CAAE) extract of the leaves of ethylene glycol (EG) in distilled water and in addition, vehicle or methanol (CAME) or … how to edit a parameter in revitWebProphylactic effects of Orthosiphon stamineus Benth. extracts on experimental induction of calcium oxalate nephrolithiasis in rats. Author links open overlay panel Yu-Sen Zhong a, Chen-Huan Yu a, Hua-Zhong Ying a, Zhi-Yuan Wang a, Hua-Fang Cai b. Show more. Add to Mendeley. Share. Cite. how to edit a pak fileWebEthylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound ... 1-based ethylene glycol. Dimethyl oxalate can be converted into ethylene glycol in high yields (94.7%) ... it induces skeletal variations and … ledbury parkWebJun 6, 2024 · For PH3 mice, the challenge was performed with 0.25 M hydroxyproline (HP) in drinking water, a condition that showed more reproducible oxalate induction in male mice . Oxalate production was moderately reduced in PH3 animals compared with EG induction in PH1, probably because of a lower water intake during the challenge, although no … ledbury park child careWebAdditional Information. Ethylene glycol is a colorless, odorless, sweet tasting compound used commercially in antifreeze. It has been utilized in suicide attempts, as a substitute for ethanol and in accidental poisonings in both children and domestic pets. 100 mL is lethal; rapid treatment can prevent damage. Half-life is three to five hours. how to edit a paint fileWebDec 15, 2004 · In Wistar rats fed ethylene glycol at 1000 mg/kg of diet (Cruzan et al., 2004), total kidney oxalate concentrations reached 0.022 mmol/g of tissue (about 22 mM) within one week. Urine oxalate concentrations were about 5–10 mM at the same time, indicating that kidney oxalate levels are higher than urine oxalate levels. ledbury park junior high school