A clone is a group of identical cells that share a common ancestry, meaning they are derived from the same cell. Clonality implies the state of a cell or a substance being derived from one source or the other. Thus there are terms like polyclonal—derived from many clones; oligoclonal —derived from a few clones; and … See more This concept of clone assumes importance as all the cells that form a clone share common ancestry, which has a very significant consequence: shared genotype. 1. One of the most prominent usage is in describing a clone of See more Most other cells cannot divide indefinitely as after a few cycles of cell division the cells stop expressing an enzyme telomerase. … See more The single-cell eukaryote Paramecium tetraurelia can undergo both asexual and sexual reproduction. Asexual or clonal reproduction occurs … See more A somewhat similar concept is that of a clonal colony (also called a genet), wherein the cells (usually unicellular) also share a common ancestry, but which also requires the products of clonal expansion to reside at "one place", or in close proximity. A clonal colony would … See more • Clone (B-cell biology) • Cloning • List of animals that have been cloned • Polyclonal antibodies • Polyclonal response See more The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity. This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with affinity maturation. B cells that respond most avidly to antigen are preferentially allowed to proliferate a…
Next-Generation Sequencing-Based Clonality Assessment of Ig …
WebMay 18, 2024 · Clonal expansion not only serves to amplify the number of specific lymphocytes to mount a robust protective response to the … WebImmunology Research Using Targeted NGS. Deeper understanding of the adaptive immune system powers better insights in its role in health and disease, leading to crucial developments in immunotherapies. The Ion Torrent immunology research portfolio enables a multi-dimensional research approach to repertoire sequencing and immune response. raes tax kissimmee
Frontiers TCR Convergence in Individuals Treated With …
WebAug 5, 2014 · We also used clonality measures, Gini index and maximum cluster size, and individual BCR sequence frequencies to determine whether overall BCR repertoire structures were faithfully retained between the repeats [ 9 ]. These diversity measures correspond to that seen in equivalent sample types in previous studies (Table 1, [ 9 ]). WebOct 19, 2024 · Nature Reviews Immunology volume ... More recent work using single-cell T cell receptor sequencing in tumour systems showed that the clonality of the tumour-infiltrating cells after PD1 blockade ... WebAug 25, 2014 · Greater clonality in the repertoire of CD8 than CD4 memory T cells. Frequency distributions of categorized clonal size bins (A) and clonality scores (B) for memory CD4 and CD8 T cells were determined as described in Fig. 2 for naïve T cells. Nondetectable clonal sizes were set at the minimal frequency of 1 in 10 6 (A). Clonality … cvavspringel carolina.rr.com