WebCapillary morphogenesis gene 2 (CMG2) is a type I mem-brane protein involved in the homeostasis of the extra- ... cleaved by the pro-protein convertase furin into a 63-kDa protein. PA63 has the capacity to oligomerize into heptameric or octameric rings, to which EF/LF can bind. The binding to WebCMG2 is a transmembrane protein that is induced during capillary morphogenesis and that binds laminin and collagen IV via a von Willebrand factor type A (vWA) domain. Of …

Imaging of anthrax intoxication in mice reveals shared and …

WebJan 4, 2012 · Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 largely stems from the fact that it is involved in two diseases, one infectious and one ... WebJul 28, 2009 · Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Proc Natl Acad Sci U S A. 2009 Jul 28;106 (30):12424-9. doi: … good sam rv parks washington coast

Pathology Outlines - Juvenile hyaline fibromatosis

WebCapillary Morphogenesis Gene-2 (CMG-2) is a widely expressed anthrax toxin receptor (ATR) family protein (1 - 3). CMG-2 is a 55 kDa type I transmembrane (TM) protein that contains a 33 amino acid (aa) signal sequence, a 284 aa extracellular domain (ECD), a 24 aa TM segment, and a 147 aa cytoplasmic domain. There are three additional isoforms. WebApr 9, 2024 · Capillary Morphogenesis Gene Protein 2 (CMG2) Mediates Matrix Protein Uptake and is Required for Endothelial Cell Chemotaxis in Response to Multiple … WebHere, we established mice with CMG2 only expressed in tumor endothelial cells (ECs) and determined the specific contribution of tumor stromal ECs to the toxin’s antitumor activity. Our results demonstrate that disruption of ERK signaling only within tumor ECs is sufficient to halt tumor growth. good sam rv towing