웹2024년 4월 3일 · As shown in Fig. 2c, the transferrin-conjugate bound only to the membrane facing the bottom compartment, consistent with localization of the transferrin receptor on or near the basolateral membrane. 웹2010년 6월 9일 · In the kidneys, OAT3 is localized in the basolateral membrane of proximal tubular cells. Like OAT1, OAT3 recognizes a broad spectrum of substrates. It mediates the high affinity transport of PAH, estrone sulfate (ES), OTA, and various drugs, including the cationic drug cimetidine, in exchange for dicarboxylates inside cells [ 31 ].
Genes Free Full-Text Claudins in Renal Physiology and Pathology
In the context of renal tubule physiology, the term basolateral membrane refers to the cell membrane which is oriented away from the lumen of the tubule, whereas the term apical or luminal membrane refers to the cell membrane which is oriented towards the lumen. The principal function of this basolateral membrane is to take up metabolic waste products into the epithelial cell for disposal into the lumen where it is transported out of the body as urine. A secondary role of the … 웹2024년 10월 18일 · Immunostaining of apical junction complex protein ZO-1 and basolateral membrane–associated protein β-catenin demonstrates that colonoids and gastroids in suspension have reversed polarity such ... rtx 3060 ti advanced oc lhr
Effective reconstruction of functional organotypic kidney …
웹2005년 9월 22일 · In drug absorption and distribution/excretion processes, permeability through polarized cells can lead to problems. The polarized cell surface is composed of an apical and basolateral membrane (further subdivided into a basal and lateral membrane) separated by a tight junction (Fig. 1).The membrane on which the drug transporter is … 웹2024년 8월 22일 · Or, as the infoldings almost reach the luminal membrane, they allow a short-cut of ions from the NKCC2 import directly to the basolateral extracellular space (via Cl − channel and pump), facilitating the continuous outflow of ions through the entire basolateral membrane. 42, 43 However, this should be accompanied by increasing osmotic pressure … 웹2024년 10월 28일 · The basolateral membrane of a polarized cell is the part of the plasma membrane that forms its basal and lateral surfaces, distinct from the apical (or lumenal) … rtx 3060 ti 1440p performance